Flumazenil in Benzodiazepine Overdose: Efficacy and Controversy

Laboratory flask with chemical symbols representing scientific research.

Flumazenil reliably reverses benzodiazepine sedation, yet most emergency physicians will go a career without giving it in an overdose. This article separates the registration trial efficacy data from the pooled adverse event evidence, sets out where the 2023 AHA focused update actually lands, and treats the question as a patient selection problem rather than a drug problem.